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pyhmmer: Python Interface to HMMER3

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library 0.12.0 ·python
verified Jun 28, 2026

pyhmmer provides high-performance Cython bindings and a Pythonic interface to the HMMER3 C library, enabling powerful sequence analysis using Hidden Markov Models. It is used for searching protein and nucleic acid sequence databases, identifying remote homologs, and building profile HMMs. The current stable version is 0.12.0, with a release cadence of several minor versions per year, indicating active development.

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