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cyvcf2: Fast VCF Parsing with Cython + HTSlib

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library 0.32.1 ·python
verified Jun 28, 2026

cyvcf2 is a Python library providing a fast Cython wrapper for HTSlib, specifically designed for efficient parsing, querying, and limited modification of VCF (Variant Call Format) and BCF files. It offers a Python-friendly interface to access genetic variation data, supporting quick iteration through variants, extraction of diverse variant attributes, and manipulation of INFO and FORMAT fields. The library is highly optimized for performance, making it suitable for processing large genomic datasets. [1, 3, 4, 8]

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